Endocrine Abstracts

Introduction: The clinical and biochemical spectrum of pituitary acromegaly is wide and variable. There are pure somatotroph tumors(ST), immunohistochemically positive only for GH, and pluri-hormonal(PL), also positive for other hormones, and they appear to have different presentations and responses to treatment.Aims: To compare the clinical presentation, imaging characteristics and response to treatment of acromegalic patients according to the pituitary...

Introduction: Congenital adrenal hyperplasia (CAH) is a genetic condition which impairs enzymatic steroidogenesis of the adrenal cortex, leading to excessive androgen production. CAH phenotype is heterogeneous. In the mildest forms, it can present with hirsutism, acne and menstrual irregularities. Problems related to gender identification arise in about 5% of people with CAH with a 46,XX karyotype.Objective: We present the case of a young female-to-male ...

Introduction: Evidence has suggested a relationship between female obesity and the outcomes of medically assisted reproduction techniques (MRT); however, the evidence regarding male obesity is still scarce and discordant. Aim: Evaluate the influence of female and male obesity on the results of MRT.Materials and methods: Retrospective analysis of 2159 couples, with and without obesity, submitted to the first treatment of medically a...

Introduction: Oestrogens and androgens modulate the effects of growth hormone (GH). Sex differences have been described in acromegaly, with conflicting results in different populations. Additionally, data on sex differences in tumour histopathology are scarce.Aims: To analyse the influence of sex and menopause status in tumour characteristics and surgical outcomes in patients with acromegaly.Materials and methods: Retrospective coh...

Introduction: Only <1% of cases of primary hyperparathyroidism (PHPT) occur during pregnancy. PHPT increases risk of complications such as miscarriage, premature birth and life-threatening maternal hypercalcemic crises. Hyperparathyroidism Jaw Tumor Syndrome (HPT-JT) is a rare inherited cause of PHPT, resulting from CDC73 gene mutations. There are a few reports described about HPT-JT in pregnancy. Although parathyroidectomy is the definite treatment for PHPT, given the sca...

Introduction: There have been more than 130 genes described in relation with the development of obesity, which condition hyperphagia and early obesity. The aim of this study is to determine the prevalence of genetic alterations in a cohort of patients with morbid obesity.Materials and Methods: We designed a descriptive cross-sectional study for a cohort of subjects with obesity grade III or higher (BMI ≥40 kg/m2), treated at endocrinolog...

Objectives: To determine the lifestyle in patients with morbid obesity in a previous group and in a group after performing bariatric surgery.Material and methods: Cross-sectional study in two groups of patients with morbid obesity one before and one after bariatric surgery attended in the Clinical Management Unit of Endocrinology and Nutrition of the Puerta del Mar Hospital in Cádiz. The clinical and analytical data of the patients, the sociodemogra...

Pituitary stalk interruption syndrome (PSIS) is a rare clinical entity characterised by an absent or thin pituitary stalk, hypoplasia of the anterior pituitary gland, and ectopic location of the posterior pituitary on magnetic resonance imaging (MRI). Presentation is on early childhood or puberty and the most common hormonal deficiencies are growth hormone (GH) and gonadotropines. We present the case of a 28-year-old female patient who consulted after 2 years in secondary amen...

Introduction: Familial hypocalciuric hypercalcemia (FHH) is a rare condition (1–2% of causes for hypercalcemia) and may be confused with primary hyperparathyroidism. Diagnosis of FHH must be suspected in patients with a family history of chronic hypercalcemia, no symptoms and low urinary excretion. This disease is due to mutations in the calcium-sensing receptor (CASR) gene. Meningiomas are common intracranial tumors (15–20% of primary neoplasms of the central nervou...

Objectives: To evaluate the prevalence in our work center of pathology of adrenal glands and to assess the efficacy of the radiology imaging in the detection of especific features and to exclude malignancy lessions.Material and Methods: We included patients who presented some adrenal lesion with histological study after surgerie between January 2010 and December 2015 in the hospitals of Albacete, Almansa and Villarrobledo. We use the Pathological Anatomy...